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Effectsresemble those of alkylating agents and radiation.It is bound to plasma proteins, penetrates tissuesand is slowly excreted unchanged in urine with at? of about 72 hrs. Themajor downside to using cell lines is that they are by defini-tion abnormal, being most often derived from cancer cellsand adapted to growth in vitro with resulting major changesin important signaling pathways controlling growth anddifferentiation Themajor downside to using cell lines is that they are by defini-tion abnormal, being most often derived from cancer cellsand adapted to growth in vitro with resulting major changesin important signaling pathways controlling growth anddifferentiation. In wet AMD, brittle blood vesselsbreak down and fragile new blood vessels grow under themacula (choroidal neovascularization from the chorio-capillaris through Bruch’s membrane into the subretinalspace).
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